Identification of BAP1-associated MicroRNAs and Implications in Cancer Development

Tikam Chand

doi:10.31487/j.ijcst.2019.01.01

Abstract

Having role in gene regulation and silencing, miRNAs have been implicated in development and progression of a number of diseases, including cancer. Herein, I present potential miRNAs associated with BAP1 gene identified using in-silico tools such as TargetScan and Exiqon miRNA Target Prediction. I identified fifteen highly conserved miRNA (hsa-miR-423-5p, hsa-miR-3184-5p, hsa-miR-4319, hsa-miR125b-5p, hsa-miR-125a-5p, hsa-miR-6893-3p, hsa-miR-200b-3p, hsa-miR-200c-3p, hsa-miR-505-3p.1, hsa-miR-429, hsa-miR-370-3p, hsa-miR-125a-5p, hsa-miR-141-3p, hsa-miR-200a-3p, and hsa-miR-429) associated with BAP1 gene. We also predicted the differential regulation of these twelve miRNAs in different cancer types.

Highlights

MicroRNAs are endogenous produced small non-codingRNAs having role in post-transcriptional gene silencing, and are considered as important regulators of eukaryotic gene expression
The human genome encodes for approximately 1800 microRNAs, that function to regulate gene expression post-transcriptionally. miRNAs are characterized by a growing class of ∼22 nt long non-protein coding
While gene expressions can be influenced by many factors, post-transcriptional gene regulation involving microRNAs is fascinating because of the breadth of their interactions facilitated by their synergistic/combinatorial relationships with target genes

Summary

Introduction

RNAs having role in post-transcriptional gene silencing, and are considered as important regulators of eukaryotic gene expression. The human genome encodes for approximately 1800 microRNAs (miRNAs), that function to regulate gene expression post-transcriptionally. RNAs [1, 2]. Due to the potential for one miRNA to target multiple gene transcripts, miRNAs are recognized as a major mechanism to regulate gene expression and mRNA translation. While gene expressions can be influenced by many factors, post-transcriptional gene regulation involving microRNAs (miRNAs) is fascinating because of the breadth of their interactions facilitated by their synergistic/combinatorial relationships with target genes. Identification of miRNAs and their targets have been an important way to unravel the role of miRNAs in the development and progression of any disease

Materials & Methods

Results

Conclusion