Abstract
Two degradants observed in a drug formulation of the hepatitis B drug entecavir (Baraclude®), 1 were shown to be identical to the products resulting from the condensation between glyceraldehyde and the guanine nucleoside. The reaction products, 2a and 2b were identified by the analysis of comprehensive NMR data to be two diastereomeric derivatives of alanine implying a novel rearrangement in the reaction between glyceraldehyde and 1.
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