Identification of acute coronary syndrome and disulfiram reaction

Abstract

[Objective] To improve the recognition of disulfiram reaction with chest pain,and reduce misdiagnosis.[Methods] The cases of disulfiram reaction reported in 100 periodicals which published in recent years and admitted in Xinxiang central hospital were collected,and analyzed statistically.[Results] The clinical manifestations of 5333 cases of disulfiram reaction patients except with disulfiram reaction of general symptoms:pale complexion,palpitation,headache,nausea,vomiting,dizziness,dyspnea,shortness of breath and so on; the clinical manifestations easy to be confused with coronary heart disease were chest distress in 3490 cases(65.4％),sinus tachycardia in 2476 cases(46.4％),hypotension in 1448 cases(27.2％),perspiration in 1044 cases(18.8％),chest pain in 663 cases (12.4％),ST-T of ECG changes in 622 cases(11.7％),feeling of impending death in 162 cases (3％),the majority of patients were misdiagnosed as acute coronary syndrom,even with emergency coronary artery angiography.The prognosis of most of the patients was good after modified diagnosis by exactly treating disulfiram reaction.[Conclusions] We should detailed asking the history of drug use and alcohol containing products in suspected acute coronary syndrome patients with chest pain and flushed face,in order to avoid the misdiagnosis. Key words: Disulfiram reaction; Chest pain; Drinking; Acute coronary syndrome