Abstract
Conventional medicine-based Chinese herbal prescriptions, have fascinatedmuch attention due to their extensive and unique diversity of biologicaleffects without toxicity and/or adverse effects. Treatment with Hachimijio-gan (Ba-Wei-Di-Huang-Wan in Chinese) improved the dysregulatedlevels of hyperglycemic condition-related oxidative stress generation,advanced glycation endproduct generation, and renal function parameters.These results indicate that Hachimi-jio-gan is a prospective therapeuticagent against the pathogenesis of diabetic nephropathy. Cornel iridoidglycosides and polyphenol are the active compounds of Corni Fructus, theactive component of Hachimi-jio-gan, against kidney damage caused bydiabetes. Additionally, major components of the Corni Fructus, morronisideand 7-O-Galloyl-D-sedoheptulose (GS) are considered to be importantcontributors to prevent and/or delay the onset of kidney damage caused bydiabetes. Chief of all, GS is expected to be developed as a novel therapeuticdrug for the diabetes-accelerated kidney damage.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
