Abstract
Upon encountering stressful environments, E coli induces the sigma factor RpoS to activate stationary phase and provide general protection against stress. To better understand the regulation of RpoS, we carried out an overexpression screen with an RpoS’‐‘LacZ fusion. This screen identified an intergenic region that increased RpoS expression and significantly slowed down growth when overexpressed. A short open reading frame within this region was sub cloned and shown to also induce RpoS expression and affect growth. Thus RpoS may be regulated by a novel small protein. This work highlights the importance of small proteins that were not originally annotated in the E coli genome.
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