Abstract
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors with the poor prognosis. Nowadays, alcohol is becoming a leading risk factor of HCC in many countries. In our study, we obtained the DEGs in alcohol-related HCC through two databases (TCGA and GEO). Subsequently, we performed enrichment analyses (GO and KEGG), constructed the PPI network and screened the 53 hub genes by Cytoscape. Two genes (BUB1B and CENPF) from hub genes was screened by LASSO and Cox regression analyses to construct the prognostic model. Then, we found that the high risk group had the worse prognosis and verified the clinical value of the risk score in alcohol-related HCC. Finally, we analyzed the tumor microenvironment between high and low risk groups through CIBERSORT and ESTIMATE. In summary, we constructed the two-gene prognostic model that could predict the poor prognosis in patients with alcohol-related HCC.
Highlights
Liver cancer is the sixth most common malignancy and the third leading cause of cancer-related death worldwide by 2020 and hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for 75%–85% cases [1]
Many treatments for Hepatocellular carcinoma (HCC) have been improved with the development of nextgeneration sequencing technology and targeted therapies [19]
It is well known that alcohol consumption is a risk factor for HCC and other cancers [21,22,23,24,25], but there are still many unknown molecular mechanisms and prognostic biomarkers in alcoholrelated HCC
Summary
Liver cancer is the sixth most common malignancy and the third leading cause of cancer-related death worldwide by 2020 and hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for 75%–85% cases [1]. With the improvement of anti-virus therapies and increase of the alcohol consumption in many regions, alcohol may become a leading role of HCC in the future [3,4,5]. Retrospective studies indicated that the tumor stage at diagnosis was influenced by the etiology and alcohol-related HCC was diagnosed at a later stage [4, 6]. A prospective study found that patients with alcoholrelated HCC have reduced overall survival time compared with patients with non–alcohol-related HCC and patients with alcohol-related HCC have worse liver function and tumor characteristics at Alcohol-Related HCC diagnosis [7]. Early detection and diagnosis is crucial for the treatment and prognosis of alcohol-related HCC. There are no effective markers for its detection and prognostic prediction
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