Abstract
BackgroundLung squamous cell carcinoma (LSCC) is a form of cancer that is associated with high rates of relapse, poor responsiveness to therapy, and a relatively poor prognosis. The relationship between long non-coding RNA (lncRNA) expression and LSCC patient prognosis remains to be established.MethodsIn the present study, we discovered that lncRNAs were differentially expressed in LSCC tumor tissues relative to normal control tissues, and we explored the prognostic relevance of these lncRNA expression patterns using data from the Cancer Genome Atlas (TCGA).ResultsThese multidimensional data were analyzed in order to identify lncRNA signatures that were associated with LSCC patient survival outcomes. Kaplan-Meier survival curves revealed prognostic capabilities for three of these lncRNAs (LINC02555, APCDD1L-DT and OTX2-AS1). A Cox regression analysis revealed this three-lncRNA signature to be significantly associated with patient survival. Further GO and KEGG analyses revealed that the predicted target genes of these three lncRNAs were also potentially involved in cancer-associated pathways.ConclusionsTogether these results thus indicate that this novel three-lncRNA signature can be used to predict LSCC patient prognosis.
Highlights
Lung squamous cell carcinoma (LSCC) is a form of cancer that is associated with high rates of relapse, poor responsiveness to therapy, and a relatively poor prognosis
Together these results indicate that this novel three-long non-coding RNA (lncRNA) signature can be used to predict LSCC patient prognosis
The language package in R was used in order to interpret the lncRNA sequencing data, while the limma package was used when assessing differential lncRNA expression between LSCC and control samples, with differential expression being expressed based upon fold change (FC) values
Summary
Lung squamous cell carcinoma (LSCC) is a form of cancer that is associated with high rates of relapse, poor responsiveness to therapy, and a relatively poor prognosis. Lung cancer mortality rates are the highest of all forms of cancer, accounting for 25 and 30% of all cancer-associated deaths in the USA and China, respectively [1, 2]. In 2015 alone, 733,000 new cases of lung cancer were diagnosed in China (69% in males and 31% in females), while 218,527 new cases were diagnosed in the USA during this same period (52% in males and 48% in females). Lung squamous cell carcinoma (LSCC) cases account for a significant fraction of overall lung cancer cases [4]. LSCC more often occurs in men, is related to the smoking of tobacco, and is often associated with high rates of relapse, poor responsiveness to therapeutic intervention, and a generally poor patient
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