Abstract
Abstract Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) has shown promise as a therapy for refractory obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). DBS currently is ‘open-loop’ with stimulation parameters remaining fixed over time. In contrast, ‘closed-loop’ DBS delivers stimulation only when a biomarker of the target symptom state indicates it is needed. One challenge to the development of closed-loop DBS for psychiatric indications is the dearth of biomarkers of symptom state. Here, we report identification of an electrophysiological depression biomarker in a patient receiving DBS in the ALIC and nearby bed nucleus of the stria terminalis (BNST) for refractory OCD. Research Category and Technology and Methods Translational Research: 1. Deep Brain Stimulation (DBS) Keywords: Closed-loop, Biomarker, OCD, DBS
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