Abstract
Aims: Melissa officinalis (Mo) and Lavandula angustifolia (La) essential oils and their major constituents ((E) - caryophyllene, caryophyllene oxide, geranyl acetate, linalool, nerol, Oct-1-en-3-ol, 3-Octanone, myrcene, allo-ocimene, p-cymene and α- terpineol) assessed by GC-MS) which are shared by these two essential oils were probed in an attempt to identify the GABA AR ligand(s).
Highlights
In the last 20 years, there has been a revival of interest in natural products and medicinal plants
The management of behavioural and psychological symptoms of dementia (BPSD) such as agitation, psychosis and mood disorders remains a major problem for people with Alzheimer’s disease (AD) in clinical care [7,8]
At 0.001mg/ml, (Mo) elicited a modest preconditioning effect, but at >0.01mg/ml (Mo) was shown to cause neurotoxicity Fig.2. the latter which is consistent with the GABAA receptor inhibitory pharmacology Fig.1. and [18]
Summary
In the last 20 years, there has been a revival of interest in natural products and medicinal plants. The great molecular diversity of the multi-subunit hetero-oligomeric GABAA receptor provides opportunities to develop novel drugs, for example for anxiety, sleep disorders, alcoholism and epilepsy by establishing the relevant molecular targets for receptor subtype specific action [15,16,17]. In this present report, we attempted to identify the component that probably accounts for GABAA receptor binding properties of the Melissa and Lavender essential oils [18,19]
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