Abstract
Three hexasaccharides, having from low to very high affinity for antithrombin, were synthesised from disaccharide building block precursors. One of them, methyl(sodium 2,3-di- O-methyl-4- O-sodium sulfonato-α- l-idopyranosyluronate)-(1→4)-[(2,3,6-tri- O-sodium sulfonato-α- d-glucopyranosyl)-(1→4)-(sodium 2,3-di- O-methyl-α- l-idopyranosyluronate)-(1→4)] 2-2,3,6-tri- O-sodium sulfonato-α- d-glucopyranoside, obtainable from a single disaccharide building block precursor, constitutes a good starting point for obtaining simple oligosaccharidic heparin mimetics able to inhibit the two coagulation factors thrombin and Factor Xa.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
