Abstract
The uptake and clearance of lung surfactant phospholipid from the alveolar space is followed by extensive degradation of the internalized phosphatidylcholine (PC) by intracellular phospholipases. Our recent studies using a specific inhibitor have demonstrated that the enzyme responsible for the bulk of PC degradation is a phospholipase A2 (PLA2) that is Ca++-independent, maximally active at acidic pH, and is localized to the lung lamellar body and lysosomal fractions. Thus, this enzyme (aiPLA2) plays a major role in the normal turnover of lung surfactant as well as in turnover of exogenous surfactant administered therapeutically.
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