Abstract
Dehydrocholic acid was administered intravenously to a patient and to rats, and its metabolites excreted into bile were studied by gas chromatography-mass spectrometry as ethyl ester-dimethylethylsilyl ether-methyloxime derivatives. Two 7β-hydroxy metabolites were identified : 3α, 7β-dihydroxy-12-oxo-5β-cholanoic acid in both human and rat bile, and 3α, 7β, 12α-trihydroxy-5β-cholanoic acid in rat bile. This indicates that human and rat livers are able to reduce the 7-oxo group in dehydrocholic acid to both 7α-and 7β-hydroxy forms.
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