Abstract
Abstract Objective To identify β-adrenergic receptor subtypes in ileum smooth muscle of the horse. Sample Population Isolated strips of equine longitudinal ileum smooth muscle and membrane preparations from smooth muscle of the intestinal wall. Procedure Functional assays and radioligand binding assays. Results Relaxation of ileum longitudinal smooth muscle proved to be mainly caused by stimulation of β-atypical and β2-adrenergic receptors. Binding studies on cell membranes indicated that the total β-adrenergic receptors population consists of 54% β-atypical, 34% β2-, and 12% β1-subtypes. Conclusions The data suggest that sympathetic relaxation of equine ileum smooth muscle depends mainly on β-atypical receptor subtypes activation, with a minor contribution by β2-subtypes. Clinical Relevance The important role of β-atypical adrenergic receptor subtypes in the relaxation of equine ileum suggests possible clinical use of selective β-atypical receptor agonists to control intestinal disturbances. (Am J Vet Res 1997;58:621–625)
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