Identification, function and mechanism of novel potential cytokines and membrane molecules of immune cells

Abstract

Event Abstract Back to Event Identification, function and mechanism of novel potential cytokines and membrane molecules of immune cells Wenling Han1*, Pingzhang Wang1 and Dalong Ma1 1 Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center; Peking University Center for Human Disease Genomics; Key Laboratory of Medical Immunology, Ministry, China Cytokines and membrane molecules are major mediators of the immune system. They have essential physiological and pathological roles. More importantly, many of them have been developed to be biomedical drugs. Therefore, it will be of great significance to identify novel potential cytokines and membrane molecules. In 1998, we characterized CKLF1 with chemotactic activity on leukocytes using SSH method. Based on CKLF, we identified another 8 genes named CMTM1 to CMTM8 using bioinformatic analysis and experimental validation. CKLF and CMTM1-8 constitute the novel gene family CMTM. They have important roles in the immune and male reproductive systems, and participate in tumorigenesis. CMTM3, CMTM5 and CMTM7 are novel potential tumor suppressor genes. In 2008, we carried out genome-wide bioinformatics analysis as well as literature data mining to characterize novel potential cytokines and membrane molecules. Now, for novel potential cytokines, we obtained 212 candidates numbered 1#-212#, constructed the eukaryotic expression vectors of 121 genes and verified 36 secreted proteins, several recombinant proteins including VSTM1-v2, FAM19A4, TMEM98 et al. have modulatory effects on immune cells. For the membrane molecules, we focus on the expression and function of VSTM1-v1、TMIGD2、LRRC25 and TMEM154, which have characteristic expression profile and might involve the proliferation and differentiation of immune cells. Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (No. 81273207 and 31270948), the Program for innovation of new drug (2013ZX09103003-023) Keywords: Cytokines, membrane molecules, tumorigenesis, CMTM, immunogenomics Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune receptors and signaling Citation: Han W, Wang P and Ma D (2013). Identification, function and mechanism of novel potential cytokines and membrane molecules of immune cells. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00187 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Wenling Han, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center; Peking University Center for Human Disease Genomics; Key Laboratory of Medical Immunology, Ministry, Beijing, China, hanwl@bjmu.edu.cn Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Wenling Han Pingzhang Wang Dalong Ma Google Wenling Han Pingzhang Wang Dalong Ma Google Scholar Wenling Han Pingzhang Wang Dalong Ma PubMed Wenling Han Pingzhang Wang Dalong Ma Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.