Abstract
KCNH2 encodes hERG1, the voltage-gated potassium channel that conducts the rapid delayed rectifier potassium current (IKr) in cardiac tissue. Reduced IKr causes the cardiac disorder long QT syndrome (LQTS), and increases the risk of cardiac arrhythmia and sudden cardiac death. We observed a hERG1-specific immunofluorescent signal within the nucleus of human stem cell-derived cardiomyocytes and neonatal rat cardiomyocytes. Using antibodies targeting distinct hERG1 channel epitopes, we mapped the nuclear hERG1 peptide to the channel's cytoplasmic C-terminal domain.
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