Abstract
A substance which inhibits norepinephrine-induced free fatty acid mobilization has been isolated from the calf midbrain. A preparation of the inhibitor, considered to be highly purified, was resolved into two distinct components by paper chromatography. Both components (designated Fractions I and II) inhibited free fatty acid mobilization in adipose tissue fragments in the presence of norepinephrine. One component (Fraction II) was identical chromatographically to an inhibitor of free fatty acid mobilization prepared from the dog hypothalamus. Fraction II has a molecular weight of 136, and appears to have the structure of a pyridylacetic acid.
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