Abstract
South African mine isolates were screened for resistance to copper, and an isolate showing the highest resistance was identified as Proteus mirabilis, a Gram-negative bacterium, by 16S rDNA gene analysis and Biolog test. A higher minimal inhibitory copper concentration at 150 mg/ml was obtained using Vataanen-Nine-Salts-Solution as a less complex medium. Studies pertaining to the copper resistance mechanism of P. mirabilis showed the organism to possess a pcoA-like gene which encodes PcoA, a putative multicopper oxidase known to protect organisms from copper–mediated toxicity at high concentrations. Key words: Proteus mirabilis, copper resistance gene, multicopper oxidase.
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