Abstract
Abstract Two rabbit serum α2-macroglobulin (α2M) allotypes, Mt-3 and Mt-4, which are distinct from the previously described Mtz1 and Mtz2 allelic allotypes of α2M, were identified. The Mt-3 and Mt-4 allotypes are controlled by a pair of alleles at an autosomal locus that appears to be closely linked to the Mtz locus and not closely linked to the Aa, Ab, or Af immunoglobulin loci, or to the Lpq lipoprotein locus. Sera from Mt-3Mt-4 heterozygous rabbits do not precipitate in agar gel double diffusion plates with either anti-Mt-3 or anti-Mt-4 antisera, but do inhibit the precipitation of each antiserum with serum from the corresponding homozygous rabbits. Serum from a heterozygous rabbit precipitates with a mixture of the two antisera, indicating that both Mt-3 and Mt-4 determinants are present on the same α2M molecule and suggesting that Mt-3 and Mt-4 determinants are each present in a smaller number than that found on molecules from homozygous rabbits. Allelic exclusion does not occur at the molecular level in the Mt-3Mt-4 heterozygous rabbit; in this respect, the Mt-3/Mt-4 system resembles the Mtz1/Mtz2 system, but is dissimilar from all other known serum allotype systems. Individual α2M molecules possess allotypic specificities of both the Mtz1/Mtz2 and Mt-3/Mt-4 systems.
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