Abstract
routine medical work-up were tested for immunoglobulin G (IgG) against H. pylori and anti-CagA antibodies by specific EIA. Results: The overall seroprevalence of H. pylori infection was 37.9 %. The prevalence of anti-H. pylori IgG in males and females was similar (19.1% and 18.6%, respectively). The prevalence of anti-CagA IgG among H. pylori seropositive patients was 43.3%. When patients were stratified into age groups at decade intervals, a steady age-related increase in seroprevalence of H. pylori infection was not observed (Figure 1). The seroprevalence of H. pylori infection showed a birth-cohort effect with a drop from 40.8% in subjects older than 31 to 18.1% in subjects 30 years old or younger (p<0.05). Conclusions: Serological prevalence of H. pylori-infection shows a significant drop in patients born after 1980 in our population. Changes in housing and increased use of antibiotics are among the possible explanations for this phenomenon.
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