Abstract
Despite the progress in the creation of synthetic drugs, herbal medicines do not lose their relevance nowadays. Triterpenoids are quite common in the plant world and exhibit a wide range of biological activity. Medicinal plants of the Lamiaceae family can accumulate mainly pentacyclic triterpenoids which demonstrate the anti-inflammatory, antioxidant, hepatoprotective, anticancer and antimicrobial properties. Nowadays a number of new, poorly-studied species of the family have been introduced in Ukraine, including Monarda fistulosa L. and Ocimum americanum L.The aim of this study was to identify the triterpenoids and to analyze the contents of their components in ethanolic extracts of M. fistulosa and O. americanum (Lamiaceae) aerial parts under the condition of their farming in West Podillya (Ukraine).Methods: foam test, sedimentation and color reaction were used to determine the presence of triterpenoids in plant material; high-performance liquid chromatography (HPLC) method was used to determine their components' content; determination was carried out on a liquid chromatograph Shimadzu LC 20 Prominence.Results. The presence of triterpenoids in M. fistulosa and O. americanum ethanolic extracts was proved by the reactions of identification and HPLC. Effective extraction of triterpene compounds from the investigated plants was achieved using 96 % and 70 % ethanol. The comparative HPLC-analysis showed significant differences in content of ursolic, euscaphic, tormentic and oleanolic acids, betulin and lupeol in the aerial parts of investigated species. The most abundant components of M. fistulosa and O. americanum herbs were the ursolic and euscaphic acids.Conclusions: It was identified the presence and evaluated the contents of 6 triterpenoids in M. fistulosa and O. americanum aerial parts. The obtained data can be used in the planning of pharmacological studies and in the chemotaxonomy of Lamiaceae family
Highlights
Despite the progress in the creation of synthetic drugs, herbal medicines do not lose their relevance nowadays
In the extracts of M. fistulosa and O. americanum raw materials obtained on the basis of high concentrations of ethanol (70 % and 96 %), a positive result was found regarding the presence of triterpene compounds in the use of the foaming test, as well as the colour and sedimentation reactions
It was identified the triterpenoids in ethanoic extracts obtained from herbs of M. fistulosa and O. americanum; the components of triterpenoids were determined by the HPLC method
Summary
Despite the progress in the creation of synthetic drugs, herbal medicines do not lose their relevance nowadays. Medicinal plants with essential oils are an important source of medical and prophylactic treatments from ancient times to the present day, in connection with which scientists are interested in their phytochemical research [2, 3]. 2. Formulation of the problem in a general way, the relevance of the theme and its connection with important scientific and practical issues. Medicinal plants of the Lamiaceae family containing essential oils have long been used in scientific and folk medicine as a source of therapeutic and prophylactic medicines [3, 4]. Along with the therapeutic and preventive action, both plants have good spice and taste qualities, which opens the possibility of their wide application in the manufacture of galenic preparations
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