Abstract
Position dependent regulation of gene expression is a common theme in eukaryotes. In Drosophila this phenomenon is known as position effect variegation and results in variable expression of genes located near boundaries between transcriptionally active euchromatin and transcriptionally inert heterochromatin (reviewed in Eissenberg 1989; Henikoff 1992). In Saccharomyces cerevisiae position dependent repression, known as silencing, is associated with the silent mating type loci, telomeres, and rDNA. Marker genes placed near the silent mating type loci (HMRa and HMLa) are efficiently silenced (Schnell and Rine 1986; Mahoney and Broach 1989) whereas marker genes placed near a telomere are stably but reversibly silenced (Gottschling et al. 1990; Renauld et al. 1993). More recently silencing was shown to be associated with the tandemly repeated rDNA array (Bryk et al. 1997; Smith and Boeke 1997). Transcriptional silencing of genes placed within the rDNA appears to be weaker than that associated with telomeres and HM loci.
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