Abstract
In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with the 1,4-diazepane skeleton, terretrione D (2), together with the known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and terretrione C (6), were isolated from Penicillium sp. CYE-87. The structures of the isolated compounds were established by spectral analysis, including 1D (1H, 13C) and 2D (COSY, multiplicity edited-HSQC and HMBC) NMR and HRESIMS, as well as comparison of their NMR data with those in the literature. The compounds were evaluated for their antimigratory activity against the human breast cancer cell line (MDA-MB-231) and their antiproliferation activity against HeLa cells. Compounds 2 and 6 showed significant antimigratory activity against MDA-MB-231, as well as antifungal activity against C. albicans.
Highlights
Secondary metabolites from plants and microbes are considered as a vital component in drug discovery and development [1,2]
Members of the phylum Porifera have received great attention from natural products chemists as producers of interesting bioactive compounds [5,6], they have become a privileged source of marine fungi [7,8,9,10,11,12,13,14] and their secondary metabolites with different bioactivities [15]
Due to the activity of the compounds against C. albicans in the disc diffusion assay, the minimum inhibitory concentration (MIC) values of the compounds were determined against this strain
Summary
Secondary metabolites from plants and microbes are considered as a vital component in drug discovery and development [1,2]. Marine-derived microbes, which have been neglected for a long time, have been isolated from different marine sources, including invertebrates, sediment and algae. These microbes were explored for the discovery of novel bioactive molecules [3,4]. Members of the phylum Porifera (sponges) have received great attention from natural products chemists as producers of interesting bioactive compounds [5,6], they have become a privileged source of marine fungi [7,8,9,10,11,12,13,14] and their secondary metabolites with different bioactivities [15]. We present the isolation, structural elucidation and biological activities of these compounds
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