Abstract
Purpose: As bloodstream infection is a significant cause of morbidity and mortality, the surveillance study is required to continuously monitor the pattern of infection and antibiotic resistance. Our study aimed to detect the antibiotic susceptibility pattern of bacteria isolated from patients in Rajshahi, Bangladesh. Subjects and Methods: This study was conducted over 2 years from January 2019 to December 2020 with a total of 1,367 suspected hemocultures of inward and outward patients in Rajshahi medical college hospital, Rajshahi, Bangladesh. The standard microbiological methods were used in this study. Results: Out of overall 35% positive growth, 34% and 37% showed blood culture infection in the year 2019 and 2020, respectively. Females (55%) were found higher than males (45%). The patients were the highest in the age group 0-10 years (46%) but the number of infections rapidly decreased in the age 11-20 years (21%) followed by a gradual reduction of infection with the increasing age. All the infections were occurred due to single culture and E. coli was accounted as the most frequent infection (39.09%) followed by Staphylococcus aureus, Candida albican, Klebsiella pneumonia, Staphylococcus epidermidis, Salmonella spp., Streptococcus viridans and Pseudomonas aeruginosa. Higher sensitivity towards Cefepime, and Meropenem was demonstrated by both Gram-negative and Gram-positive bloodborne bacteria. A terrifying scenario was that a great number of those isolates showed resistance towards 4, 6, and more than 6 antibiotics, respectively. Conclusion: Our local work on bacteriological profile and antibiogram might help to rationalize empiric treatment strategies.
Highlights
A disease that is transmitted by blood or body fluid is known as blood-borne disease
Staphylococcus, Streptococcus and Enterococcus species are the major gram-positive bacteria that can enter the bloodstream during infection (Rolston et al, 2006)
A total of 1,367 samples of inward and outward patients clinically suspected as having bacteremia were evaluated for our study
Summary
A disease that is transmitted by blood or body fluid is known as blood-borne disease. Blood is normally sterile until it is contaminated (Castillo et al, 2019). The presence of microorganisms in the blood is addressed by different terms, like bacteremia (presence of bacteria in the blood), viremia (presence of virus in the blood), fungemia (presence of fungi in the blood) (Viscoli, 2016). Gram-negative bacteria are more common in bacteremia causing 25% of nosocomial infections and 45% of community-acquired infections (Gaynes & Edwards, 2005; Diekema, 2003). The common gram-negative bacteria that are responsible for bacteremia include Escherichia coli, Pseudomonas, Klebsiella, Serratia, Under the license CC BY- 4.0. Staphylococcus, Streptococcus and Enterococcus species are the major gram-positive bacteria that can enter the bloodstream during infection (Rolston et al, 2006)
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