Abstract

 CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
 The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
 This review assesses idecabtagene vicleucel (Abecma), cell suspension in 1 or more patient-specific infusion bag(s); target dose of 450 × 106 CAR T cells, within a range of 275 × 106 to 520 × 106 CAR T cells; for IV infusion.
 Indication: For the treatment of adult patients with multiple myeloma who have received at least 3 prior therapies, including an immunomodulatory drug, a proteasome inhibitor, and an anti-CD38 antibody, and who are refractory to their last treatment.
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