IDDF2021-ABS-0152 Gallbladder polyps are associated with gastrointestinal polyps

Abstract

<h3>Background</h3> To date, it is not clarified whether patients with gallbladder diseases need gastroscopy and colonoscopy screening. The objective of this study is to retrospective determine the association between gallbladder diseases and gastrointestinal polyps. <h3>Methods</h3> A retrospective cross-sectional study included patients who underwent gastroscopy, colonoscopy and abdominal ultrasound as a part of health check-up from January 2015 to July 2020. Gastroscopy and colonoscopy results were divided into four groups by endoscopic findings: polyps-free group, gastric polyps group, colorectal polyps group and gastric plus colorectal polyps group. We compared patients with and without gallbladder diseases for the prevalence of gastrointestinal polyps. The odds ratios (OR) were computed by logistic regression analysis after multivariable adjustment. <h3>Results</h3> Totally 1652 patients were included, with 958 patients in the polyps-free group, 504 in the colorectal polyps group, 109 in the gastric polyps group and 91 in the gastric plus colorectal polyps group. Patients with gallbladder polyps had greater odds of having colorectal polyps (adjusted OR=1.77, 95% confidence interval [Cl]: 1.23 to 2.54, p=0.002) and gastric plus colorectal polyps (adjusted OR=2.94, 95%Cl: 1.62 to 5.32, p&lt;0.001) than those without. Subgroup analysis found that patients with gallbladder polyps larger than 0.5 cm had greater odds of having colorectal polyps (adjusted OR=2.21, 95% confidence interval [Cl]: 1.35 to 3.64, p=0.002) and gastric plus colorectal polyps (adjusted OR=3.16, 95% confidence interval [Cl]: 1.39 to 7.17, p=0.006) and that women with gallbladder polyps had higher prevalence of colorectal polyps (OR=2.13, 95% CI: 1.20 to 3.77, p=0.010) as well as gastric plus colorectal polyps (OR=3.69, 95% CI: 1.58 to 8.62, p=0.003). We did not find a positive correlation between gallbladder stones and gastrointestinal polyps. <h3>Conclusions</h3> The presence of gallbladder polyps is significantly associated with colorectal polyps and gastric plus colorectal polyps. Gastroscopy and colonoscopy screening might be considered in patients with gallbladder polyps, especially females.