IDDF2020-ABS-0218 The values of acoustic radiation force impulse elastography of liver in evaluating the degree of liver fibrosis in alcoholic liver disease

Abstract

Background Prevalence of alcoholic liver disease (ALD) is increasingly elevated all over the world. The degree of liver fibrosis (LF) is an important factor that affects the treatment and prognosis. Acoustic radiation force impulse (ARFI) elastography is a noninvasive and a new way of assessing LF. Aims To evaluate the diagnostic performance of ARFI elastography for assessing LF in ALD. Methods This prospective study included 40 patients with ALD at Thai Nguyen National Hospital from June 2019 to February 2020. These patients had been diagnosed with ALD according to the guideline of the AASL 2010. Collecting samples for laboratory testing. Liver stiffness measurement was done using ARFI elastography. Liver biopsy was graded using Metavir classification. Results Majority were in age group of 41–50 years (63%). The mean ARFI elastometry showed 2.71 ± 0.59 m/s (range 0.86–4.53) in 40 male patients. Shear wave velocity (SWV) significantly correlated with the fibrosis stage. The area under the ROC curves (AUROCs) for diagnosis of ≥ F2 and ≥ F3 were 0.87 (95% CI: 0.78–0.95) and 0.89 (95% CI: 0.81–0.97), respectively. The cut-off values of SWV for ≥ F2 and ≥ F3 were 1.98 m/s (Se 78.25%, Sp 88.37%, PPV 85.6% and NPV 82.4%) and ≥ 2.31 m/s (Se 95.68%, Sp 85.58%, PPV 71.6%, NPV 97.8%), respectively. APRI significantly correlated with the fibrosis stage. AUROCs for diagnosis of ≥ F2 and ≥ F3 were 0.8 (95% CI: 0.58–0.76) and 0.78 (95% CI: 0.84–0.82), respectively. The cut-off values of APRI for diagnosis of ≥ F2 and ≥ F3 were ≥ 0.62 (Se 51.1%, Sp 87.13%, PPV 72.3% and NPV 68.1%) and ≥ 1.171 (Se 42%, Sp 95.52%, PPV 81%, NPV 83.1%), respectively. Conclusions Increasing SWV correlates with a higher degree of LF. ARFI elastography is a noninvasive, reliable, and repeatable diagnostic test in evaluating the degree of LF.