IDDF2019-ABS-0104 Gastrointestinal cytomegaloviral infection in immunocompetent patients is associated with more severe illnesses and has a higher mortality rate compared to infection in immunocompromised patients

Abstract

Background Gastrointestinal (GI) cytomegaloviral (CMV) infection is common among patients with immunocompromised (ICM) status. There have been some case reports in immunocompetent (ICT) patients, but the data are limited. Methods A retrospective study of all patients diagnosed with CMV GI disease by demonstration of CMV viral inclusion or immunohistochemistry on tissue pathology from 2008 to 2017 in a tertiary referral center was performed. Immunocompromised patients included patients with AIDS, organ transplantation, or received chemotherapy, systemic corticosteroids, or immunosuppressive agents. The baseline characteristics, presentation, comorbid conditions, treatment, and outcomes were compared between the patients with ICT and ICM status. Results 173 patients comprising 56 ICT and 117 ICM patients were included. ICT patients were older than ICM patients with a mean age of 73 and 48.6 years, respectively (p Conclusions CMV GI disease in ICT patients was frequently developed in elderly and half-developed while hospitalization. Gastrointestinal bleeding was the most common presentation. The CMV disease in ICT patients was associated with more severe illnesses and a higher mortality rate. CMV viral load was not helpful in diagnosis.