Abstract
Recent advances in spinal cord stimulation (SCS) have focused on two highly novel areas; (1) differential target, multiplexed (DTM) SCS [1], which has demonstrated superior pain relief, and (2) the spinal Evoked Compound Action Potential (ECAP), a bioelectrical signal used as a measure of neural activation with closed-loop (CL) SCS systems to compensate for motion at the electrode-tissue interface [2]. Simultaneous application of both approaches may allow for a new generation of neural responsive SCS that blends a science-based methodology for pain management with real-time, CL control for biophysical variation. In this study, CL DTM-SCS was explored to assess feasibility in a home
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