Abstract

In an animal model of chronic neuropathic pain, spinal cord stimulation (SCS) utilizing a differential target multiplexed programming (DTMP) demonstrated significant improvements in pain-like behavior (i.e. mechanical and thermal hypersensitivity) and modulated gene expression within pain-related biological processes toward the levels of naïve animals.1,2,3 This work has been translated successfully to the clinic (DTM™ SCS) in patients with chronic pain.4 This study presents the results of a reduced energy derivative of DTMP using the same animal model.

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