Abstract
Contrary to old dogma, recent data suggests that in patients with cirrhosis and coagulopathy, prolongation of the INR does not accurately reflect hemostasis or thrombin formation. With chronic liver disease, not only is there a decrease in production of procoagulant factors there is a simultaneous reduction in the production of anticoagulant factors as well, often resulting in normal coagulation. Therefore, because the INR is reflective only of the procoagulant pathway it can be misleading in regards to bleeding risk in cirrhotic patients. The purpose of this study was to investigate whether giving fresh frozen plasma (FFP) prior to invasive procedures for patients with cirrhosis and coagulopathy reduces the incidence of procedure related bleeding.
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