Abstract
Learning of skilled movement requires coincident activation of motor and sensory connections. In rats we have developed a spinal cord associative plasticity protocol which relies on synchronized stimulation of the brain and cervical spinal cord. Immediate facilitation of cortical motor evoked potentials occurs when spine and brain stimulation are timed to converge in the spinal cord. Repeated application of these synchronized pulses for 5-30 minutes induces lasting changes in spinal excitability and produces improvements in dexterity in rats [1-2]. We hypothesized that appropriately timed epidural stimulation targeting the dorsal root entry zones of the human cervical spinal cord would facilitate cortical motor evoked responses in people.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Neuromodulation: Technology at the Neural Interface
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
