Abstract
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic idiopathic inflammatory disorder. While immunomodulators and biologics are available to induce and maintain remission, long-term efficacy is limited by the loss of response and serious side effects in more than 30% of patients. Vagal nerve stimulation has been reported to treat UC with promising results. On the other hand, sacral nerve stimulation (SNS) has been shown to exert anti-inflammation effects in rodent models of UC with an interesting spinal afferent and vagal efferent pathway. Accordingly, we hypothesized that SNS may also be able to modulate functions of organs that are innervated with vagus nerve but not sacral nerve. The aim of this study was to investigate possible anti-inflammatory effects of SNS on ileal inflammation in a rodent model of CD.
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