Abstract
The function of the intervertebral disc is structural. Degenerative change with accompanying tissue loss alters biomechanics and leads to subsequent disc degeneration that has been correlated with discogenic pain1. Multiple cell products have now been assessed clinically with promising results as non-surgical options to treat discogenic low back pain. A novel acellular nucleus pulposus (NP) allograft has been developed to replace the loss of NP tissue in degenerated discs. Taking advantage of the hydrophilic and viscous properties of the NP tissue, the strategy in supporting the mechanical cushioning of the disc is to provide comparable outcomes to those obtained with cellular allografts.
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