Abstract
Is there a way to pre-operatively identify epilepsy patients who best respond to neuromodulation? One-third of patients with epilepsy experience seizures that are resistant to medication. Furthermore, resective and/or ablative surgeries may be contraindicated. Closed-loop neuromodulation — for instance, responsive neurostimulation (RNS) — is a promising treatment option. However, clinical outcomes vary widely across patients.1 Researchers have used pre-operative global connectivity from magnetoencephalography (MEG) signals, as well as global measures of synchronizability from intracranial EEG (iEEG), as pre-operative electrographic biomarkers associated with successful RNS outcomes.2,3 An analysis specific to the RNS-implanted regions may allow for a better understanding of the patient-specific response to RNS therapy. Thus, we seek to use pre-operative iEEG recordings of eventual RNS implanted regions to investigate possible electrographic biomarkers of successful RNS therapy.
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