Year-end Sale % OFF 
Abstract
The extreme diversity of the human immune system, forged and maintained throughout evolutionary history, has to date provided a potent defense against pathogens [1]. Intrinsically variable autonomic neuro-immune regulation via β-adrenergic receptor and α7-nicotinic acetylcholine receptor activity is controlled by polymorphic genes and environmental sensors [2, 3]. While most healthy humans have the capacity to activate various types of immune cells, interferons, inflammasome activity, and vagal anti-inflammatory reflexes, individuals differ in the degree to which they are primed for each functional configuration. Virulent emerging pathogens inherently circumvent these functional immune configurations and can impose a dysregulated hyperinflammatory response [4]. Here we detect host-dependent baseline autonomic gradient drive (AGD) bias through high temporal resolution physiological monitoring. Similar to immune bias, AGD bias shown to predict current inflammatory status as well as severity of future inflammatory sequela and disease.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Neuromodulation: Technology at the Neural Interface
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
