Abstract
Dorsal root ganglion stimulation (DRG-S) places an electrical field over the DRG to modulate neural transmission. As mechanisms underlying DRG-S have become elucidated, it is clear there are actions distinct from that of conventional spinal cord stimulation (SCS). DRG-S is efficacious when delivered as a subthreshold and paresthesia-free tonic waveform, at frequencies as low as 4 Hz, and when stimulation is delivered intermittently, none of which are possible with SCS. The endogenous opioid system may play a role in pain relief with DRG-S, which should lead to prolonged washout times based on preclinical research. This study aimed to measure the time for pain to return to baseline pain levels after subjects’ 1-week DRG-S trials ended.
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