ID: 207630 MR Thermal Imaging for Low Intensity Focused Ultrasound Modulation of Spinal Nervous Tissue

Abstract

In multiple models of pain across rodents and swine, we have shown that external low intensity focused ultrasound (liFUS) can be delivered to modulate pain responses.1 In previous work, a single thermocouple was used to ensure that liFUS therapy stimulates the target (L5 dorsal root ganglia (DRG)) with no adverse heating. To increase confidence that no adverse heating occurs in/ around the entire L5 DRG region, we examine whether magnetic resonance thermometry imaging (MRTI) can accurately assess thermal changes in 2D/ 3D in the region.