Abstract
Peripheral nerve stimulation (PNS) is an evolving modality for treating different chronic pain conditions. The intervention was predicated on the gate theory of pain, which posits nociceptive and non-nociceptive inputs modulate the other's intensity in the dorsal horn of the spine. Although gate theory was one of the first explanations of PNS, competing theories now include overstimulation of c-fibers, exhaustion of neurotransmitters, fixed depolarization of afferent axons, and electrically induced changes to long term potentiation.1 No unified mechanism has been established, though the efficacy of PNS is evident.
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