Abstract
In vitro glial cell models can be used to assess changes that might correlate with putative molecular effects that electrical stimulation (ES) could have on neuroglia. Cell models allow for faster and cheaper experiments than animal models due to the potential to easily vary the conditions, reduce the number of variables, and closely monitor specific effects. We previously showed that modulation of gene expression in cultured C6 glioma cells, an astrocyte model system, was dependent on the anodic content of electrical stimulation (ES)1. Expanding on this research, we assessed molecular changes in response to passively balanced cathodic ES pulses in the presence of neurotransmitters.
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