ID: 203253 Electrochemical Characterization of the First FDA-Cleared Thin-Film Electrodes for Recording and Stimulation of Brain Activity

Abstract

Introduction: Subdural strip and grid (SDE) and stereoelectroencephalography (sEEG) electrodes are essential tools for pre-surgical evaluation of patients suffering from drug resistant epilepsy (DRE). Both device types are used to precisely localize the origin and spread of seizures and the relationship with eloquent cortex. The electrodes must accurately and reliably record brain activity over a wide frequency band needed for seizure event detection and deliver electrical stimulation within safety limits for brain mapping. The ability of the devices to meet these performance criteria is tested using electrochemical evaluation, which is a critical step in the path to commercialization of implantable medical devices. Driven by a constant need to develop new technologies or improve upon existing ones with potential to enhance the tissue/electrode interaction, here we present a thorough electrochemical characterization of two implantable thin-film SDG and sEEG arrays.??