ID:16509 Long-Term Ecological Assessment of Intracranial Electrophysiology Synchronized to Behavioral Markers in Obsessive-Compulsive Disorder

Abstract

Despite the promise of deep brain stimulation (DBS) targeted to the ventral capsule/ventral striatum for treatment of severe obsessive-compulsive disorder (OCD), 25-40% of individuals do not respond to DBS treatment. This may be due to the current ‘open loop’ stimulation paradigm, where constant stimulation parameters do not address the dynamic nature of OCD symptoms. Adaptive deep brain stimulation (aDBS) has emerged as a potential strategy for improving efficacy of DBS for OCD. In an aDBS system, stimulation parameters are automatically adjusted based on detection of neural signatures related to symptoms or side effects of DBS.