ID 112 – Both sensory and cognitive networks are affected in Parkinson’s disease

Abstract

Objective Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder which affects both motor and cognitive functioning. This study aims to investigate the sensory evoked oscillations (SEO) and event-related oscillations (ERO) of visual modality in cognitively normal PD patients and healthy controls. Methods Sixteen PD and 16 matched control subjects were participated to the study. Simple flashlight was used for SEO and a classical visual oddball paradigm was used for target ERO. Oscillatory responses in delta frequency range (0.5–3.0 Hz) were examined. Results Significant differences were found between groups on the maximum peak-to-peak amplitudes of both delta ERO and SEO responses [ F 1.27 = 8.573, p = 0.007; F 1.27 = 6.306, p = 0.018, respectively], indicating significantly lower delta responses in PD than healthy controls. Delta ERO responses were decreased in PD in frontal, central and parietal locations ( p Conclusions In this study, both target delta ERO and SEO responses were decreased in PD. According to the notion that the activity of sensory networks are reflected by SEO and cognitive networks by ERO, these findings indicate that PD patients have impairments in both networks of visual modality. Brain oscillatory responses have a potential to be searched as a biomarker for visual cognitive and sensory status of PD.