Abstract
Mike’s laboratory utilises molecular genetic, cultured cell, biochemical and structural, bioinformatic and cohort-based methodologies to study the biological principles that underpin HIV replication and pathogenesis (AIDS). Current areas of interest include host-virus interactions, cell-encoded mechanisms of anti-viral resistance and virus particle assembly. Over the last ten years, much of his group’s work has been devoted to the viral protein Vif; and it was through these efforts that the human anti-HIV gene APOBEC3G was recognised and characterised. More recently, his group identified the interferon-induced gene MX2 as a novel mediator of resistance to HIV infection that suppresses virus entry into the nucleus.
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