Abstract
Objective Regional differences in nerve excitability have been associated with susceptibility to entrapment neuropathy. The aim of this study was to identify any differences in axonal excitability between the median nerve (MN) motor axons supplying the L2 and APB. Methods Computerized nerve-excitability testing was used to examine the axonal excitability of the MN motor axons of both the L2 and APB in 30 healthy volunteers. Results The rheobase was significantly lower and the strength-duration time constant was significantly longer in the MN motor axons supplying the APB than in those supplying the L2 ( P Conclusion Together these findings indicate that this pattern of alteration of excitability parameters can be attributed to the MN motor axons supplying the APB being more depolarized than those supplying the L2. Significance Axonal excitability differs significantly even along the distal MN. Selective L2 sparing in carpal tunnel syndrome may have a biophysical contribution; that is, regional differences in axonal excitability and vulnerability to repetitive physiological demands.
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