Abstract
The Hypoviridae, comprising one genus, Hypovirus, is a family of capsidless viruses with positive-sense, ssRNA genomes of 9.1-12.7 kb that possess either a single large ORF or two ORFs. The ORFs appear to be translated from genomic RNA by non-canonical mechanisms, i.e. internal ribosome entry site-mediated and stop/restart translation. Hypoviruses have been detected in ascomycetous or basidiomycetous filamentous fungi, and are considered to be replicated in host Golgi-derived, lipid vesicles that contain their dsRNA as a replicative form. Some hypoviruses induce hypovirulence to host fungi, while others do not. This is a summary of the current ICTV report on the taxonomy of the Hypoviridae, which is available at www.ictv.global/report/hypoviridae.
Highlights
Capsidless virus unable to form rigid particles 9.1–12.7 kb of linear, positive-sense, non-segmented RNA Replication and transcription occur cytoplasmically in Golgi-derived membraneous vesicles Directly from bi- or monocistronic genomic RNA containing a possible internal ribosomal entry site at the 5¢-non-coding region Fungi One genus including four species
No true virions are associated with members of the family Hypoviridae
Pleomorphic vesicles 50–80 nm in diameter [1], devoid of any detectable viral structural proteins but containing replicative form dsRNA and polymerase activity [2], are the only virus-associated particles that can be isolated from infected fungal tissue (Table 1, Fig. 1)
Summary
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