Abstract
1 shows a map of voxels with HRs greater than 2 (p 0.05), representing regions where increased atrophy more than doubled risk of progression. The color scale in the Figure indicates the range of significant HRs, with blue corresponding to HR of 2 and red to HR of 6. Not surprisingly, the greatest risk of progression to AD is associated with atrophy of the medial and basal temporal lobes. Other areas of atrophy associated with increased risk of progression are the lateral temporal and parietal neocortex. Conclusions: We have applied time-to-event statistical methods to SPM5 derived GMD estimates in a novel way to identify regions of atrophy that significantly increases aMCI patients’ risk of progression to dementia. In the context of a progressive disease like AD, time-to-event VBM seems more appropriate than traditional two-sample methods.
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