Abstract
BackgroundVariety of information relating between genome and the pathological findings in disease will yield a wealth of clues to discover new function, the role of genes and pathways, and future medicine. In addition to molecular information such as gene expression and genome copy number, detailed clinical information is essential for such systematic omics analysis.ResultsIn order to provide a basic platform to realize a future medicine based on the integration of molecular and clinico-pathological information of disease, we have developed an integrated clinical omics database (iCOD) in which comprehensive disease information of the patients is collected, including not only molecular omics data such as CGH (Comparative Genomic Hybridization) and gene expression profiles but also comprehensive clinical information such as clinical manifestations, medical images (CT, X-ray, ultrasounds, etc), laboratory tests, drug histories, pathological findings and even life-style/environmental information. The iCOD is developed to combine the molecular and clinico-pathological information of the patients to provide the holistic understanding of the disease. Furthermore, we developed several kinds of integrated view maps of disease in the iCOD, which summarize the comprehensive patient data to provide the information for the interrelation between the molecular omics data and clinico-pathological findings as well as estimation for the disease pathways, such as three layer-linked disease map, disease pathway map, and pathome-genome map.ConclusionsWith these utilities, our iCOD aims to contribute to provide the omics basis of the disease as well as to promote the pathway-directed disease view. The iCOD database is available online, containing 140 patient cases of hepatocellular carcinoma, with raw data of each case as supplemental data set to download. The iCOD and supplemental data can be accessed athttp://omics.tmd.ac.jp/icod_pub_eng
Highlights
Variety of information relating between genome and the pathological findings in disease will yield a wealth of clues to discover new function, the role of genes and pathways, and future medicine
More detailed clinical/environmental information in combination with the molecular information is needed to elucidate the whole process of the complex diseases such as cancer
We developed several kinds of integrated view maps of disease in our integrated clinical omics database (iCOD), which summarize the comprehensive patient data to provide the information for the interrelation between the molecular omics data and clinico-pathological findings as well as estimation for the disease pathway, such as three layer-linked disease map, disease pathway map, and pathome-genome map
Summary
Variety of information relating between genome and the pathological findings in disease will yield a wealth of clues to discover new function, the role of genes and pathways, and future medicine. We have first developed an integrated clinical omics database (iCOD), a basic platform where comprehensive disease information of the patient is collected This database includes molecular omics data such as CGH (Comparative Genomic Hybridization) and gene expression profiles and comprehensive clinical information such as clinical manifestations, medical images (CT, X-ray, ultrasounds, etc), laboratory tests, drug histories, pathological findings and even life-style/environmental information, and gene search menu, related to these clinical information. We developed several kinds of integrated view maps of disease in our iCOD, which summarize the comprehensive patient data to provide the information for the interrelation between the molecular omics data and clinico-pathological findings as well as estimation for the disease pathway, such as three layer-linked disease map, disease pathway map, and pathome-genome map. Our iCOD aims to clarify the omics basis of the disease as well as to promote the pathway-directed disease view
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