Abstract
Ichthyosis uteri is a rare pathological condition characterized by the replacement of the endometrial lining by stratified squamous epithelium. Yet its occurrence with endometrial adenocarcinoma is very rare. A 68-year-old woman has been experiencing sporadic, minor vaginal hemorrhages for a few months. The gynecological evaluation revealed a uterine enlargement and imaging demonstrated an irregular mass within the uterus. Endometrial adenocarcinoma with transitional cell differentiation; ichthyosis uteri with dysplasia. Radical hysterectomy with pelvic lymphadenectomy was performed followed by postoperative radiotherapy. Postoperative follow-up at 8 months showed a favorable outcome without signs of recurrence and metastasis. Adequate pathological sampling is crucial to identifying the accompanying lesions of ichthyosis uteri. Finding molecular alterations in various pathological morphologies is important to understand the evolution of disease.
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