Abstract
To date, various studies have found that the occurrence of cancer may be related to viral infections. Therefore, it is important to explore the relationship between viruses and diseases. The International Agency for Research on Cancer has defined six types of viruses as Class 1 human carcinogens, including Epstein–Barr virus, hepatitis C virus, hepatitis B virus, human T-cell lymphotropic virus, human herpesvirus 8 and human papillomavirus, while Merkel cell polyomavirus is classified as ‘probably carcinogenic to humans’ (Group 2A). Therefore, in-depth research on these viruses will help clarify their relationship with diseases, and substantial efforts have been made to sequence their genomes. However, there is no complete database documenting these cancer-associated viruses, and researchers are not able to easily access and retrieve the published genomes. In this study, we developed iCAV, a database that integrates the genomes of cancer-related viruses and the corresponding phenotypes. We collected a total of 18 649 genome sequences from seven human disease-related viruses, and each virus was further classified by the associated disease, sample and country. iCAV is a comprehensive resource of cancer-associated viruses that provides browse and download functions for viral genomes. Database URL: http://icav.omicsbio.info/
Highlights
Since the early 1900s, various studies have reported the carcinogenic properties of retroviruses [1]
To obtain the complete genome sequences, we first filtered the results by the range of genome length, which was defined as the known approximate length, and removed the sequences that only contain a portion of a genome (Table 1)
Our data were related to 87 phenotypes and 66 sample types, which originated from 143 countries worldwide, while the data types of each virus are presented in Figure 1, Tables 2 and 3
Summary
Since the early 1900s, various studies have reported the carcinogenic properties of retroviruses [1]. Evidence of the association between cancers and infections with certain viruses has been accumulating, and people have identified several cancer-associated viruses, including EBV, human papillomavirus (HPV), Kaposi’s sarcoma-associated herpesvirus (KSHV; known as human herpesvirus 8, HHV8), hepatitis C virus (HCV), hepatitis B virus (HBV), Merkel cell polyomavirus (MCV) and human T-cell lymphotropic virus (HTLV) [3]. Infection with these viruses is the etiology of approximately 15% of all cancer cases worldwide [4]. The retrovirus human T-cell lymphotropic virus type 1 (HTLV-1) has infected 10–20 million people, Database, Vol 2021, Article ID baab
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