ICanClean Improves Independent Component Analysis of Mobile Brain Imaging with EEG.

Abstract

Motion artifacts hinder source-level analysis of mobile electroencephalography (EEG) data using independent component analysis (ICA). iCanClean is a novel cleaning algorithm that uses reference noise recordings to remove noisy EEG subspaces, but it has not been formally tested in a parameter sweep. The goal of this study was to test iCanClean’s ability to improve the ICA decomposition of EEG data corrupted by walking motion artifacts. Our primary objective was to determine optimal settings and performance in a parameter sweep (varying the window length and r2 cleaning aggressiveness). High-density EEG was recorded with 120 + 120 (dual-layer) EEG electrodes in young adults, high-functioning older adults, and low-functioning older adults. EEG data were decomposed by ICA after basic preprocessing and iCanClean. Components well-localized as dipoles (residual variance < 15%) and with high brain probability (ICLabel > 50%) were marked as ‘good’. We determined iCanClean’s optimal window length and cleaning aggressiveness to be 4-s and r2 = 0.65 for our data. At these settings, iCanClean improved the average number of good components from 8.4 to 13.2 (+57%). Good performance could be maintained with reduced sets of noise channels (12.7, 12.2, and 12.0 good components for 64, 32, and 16 noise channels, respectively). Overall, iCanClean shows promise as an effective method to clean mobile EEG data.